A structured Summary of ESMO's Clinical Practice Guidelines for Early Stage and Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Title: Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Publication Date: August 28, 2025 – Annals of Oncology
Authors: Zer A, Ahn MJ, Barlesi F, et al., on behalf of the ESMO Guidelines Committee.
Published in Annals of Oncology on August 28, 2025, new ESMO guidelines represent a critical resource for clinicians navigating the complexities of diagnosis, treatment, and long-term management of this challenging disease. Developed by a multidisciplinary team of global experts, these guidelines integrate the latest scientific evidence with consensus-based recommendations to ensure standardized, high-quality care. By offering clear treatment algorithms for both resectable and unresectable cases, they aim to improve outcomes and guide clinical decision-making in NSCLC.
Guideline Objectives
Target Audience: Healthcare professionals managing early stage and locally advanced non-small cell lung cancer (NSCLC).
Scope:
Diagnosis and staging of the disease.
Risk assessment to tailor management.
Treatment recommendations, including therapeutic algorithms for resectable and unresectable cases.
Follow-up protocols for patients post-treatment.
Key Features
Treatment Algorithms: Provided to guide therapeutic decisions for resectable and unresectable disease.
Comprehensive Approach: Covers diagnosis, treatment, and follow-up to optimize patient care.
esmo.org/guidelines/esmo-clini…
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